6.4.2 Male sex hormones and antagonists

6.4.2 Male sex hormones and antagonists

Used for replacement therapy in pituitary or testicular disease.

NOT licensed or indicated for use in increasing libido

AMBER Testosterone Link to Shared Care Guideline

SHARED esters injection (Sustanon 100®, Sustanon 250®)

CARE depot injection 250mg/mL (Nebido®)

transdermal gel 16.2mg/gram pump (Testogel®pump)*

(*One pump actuation delivers 1.25g of gel containing 20.25mg of testosterone)

transdermal gel 20mg/1gram pump dispenser (Tostran®)**

(**One press of the canister piston delivers 0.5 g of gel containing 10 mg testosterone).

transdermal gel 20mg/1gram pump dispenser (Testavan®)

The dose should be applied either to the abdomen, or spread over both inner thighs.

Anti-androgens

Finasteride is used for benign prostatic hyperplasia, cyproterone is used for severe hypersexuality and sexual deviation in males,

and to treat hyperandrogenism in women with polycystic ovary syndrome (unlicensed).

GREEN Cyproterone tablets 50mg (Androcur®)

GREEN Finasteride tablets 5mg

Dutasteride

Consultant Urologist initiation only then primary care prescribing. Only to be used for 1 years treatment, when patients should be

reviewed by the consultant urologist to either stop dutasteride, switch to finasteride, or progress to other management strategies

and this communicated to the GP. Dutasteride is restricted for a high risk patient group, used in combination with tamsulosin in

patients with moderate to severe symptoms (IPSS>12) with larger prostates (>30cc) and elevated PSA (>1.5ng/mL).

AMBER Dutasteride capsules 500mcg (Avodart®)

All material in this section is aimed at health care professionals, but is information currently held in the public domain, members of the

public seeking advice on medicine-related matters are advised to speak with their GP, pharmacist, nurse or contact NHS111 Service.

Email: info.elmmb@nhs.net