5.3.1 HIV Infection
Please refer to Lancashire Formulary for AntiRetroviral Therapy (ART) - click here
Nucleoside reverse transcriptase inhibitors
RED Abacavir tablets 300mg (NHS England Commissioned) |
RED Abacavir with Lamivudine tablets 300mg, 600mg ( Kivexa®) (NHS England Commissioned) |
RED Zidovudine 300mg, lamivudine 150mg (Combivir®) (NHS England Commissioned) |
RED Didanosine (NHS England Commissioned) |
tablets 25mg, capsules e/c 250mg, 400mg |
RED Lamivudine tablets 100mg,150mg (NHS England Commissioned) |
RED Tenofovir tablets 245mg (NHS England Commissioned) |
RED Tenovir 245mg, emtricitabine 200mg tablets (Truvada®) (NHS England Commissioned) |
RED Zidovudine (NHS England Commissioned) |
capsules 100mg, 250mg |
syrup 50mg/5mL |
Protease inhibitors
RED Atazanavir capsules 150mg, 200mg, 300mg Second line use only (NHS England Commissioned) |
RED Darunavir tablets 75mg, 150mg, 400mg, 600mg (NHS England Commissioned) |
Second line use only oral suspension 100mg/mL |
RED Fosamprenavir tablets 700mg (NHS England Commissioned) |
RED Glecaprevir with pibrentasvir NICE TA499 (NHS England Commissioned) |
RED Indinavir capsules 200mg (NHS England Commissioned) |
RED Kaletra® tablets (lopinavir 200mg, ritonavir 50mg) (NHS England Commissioned) |
RED Nelfinavir tablets 250mg (NHS England Commissioned) |
RED Ritonavir capsules 100mg (NHS England Commissioned) |
RED Saquinavir capsules 200mg (NHS England Commissioned) RED Elbasvir-grazoprevir tablets 50mg, 100mg NICE TA 413 (NHS England Commissioned |
Non-nucleoside reverse transcriptase inhibitors
RED Efavirenz, tablets 600mg, capsules 200mg (NHS England Commissioned) |
RED Etravirine tablets 100mg, 200mg Third line use only (NHS England Commissioned) |
RED Nevirapine tablets 200mg (NHS England Commissioned) |
Other antiretrovirals
RED Raltegravir tablets 400mg (NHS England Commissioned) |
RED Maraviroc tablets 150mg, 300mg (Celsentri®) (NHS England Commissioned) |
5.3.2 Herpesvirus infections
5.3.2.1 Herpes simplex and varicella-zoster infection
GREEN Aciclovir |
tablets 200mg, 400mg, 800mg |
suspension 200mg/5mL |
injection 250mg/10mL, 500mg/20mL, 1000mg/40mL AMBER Famciclovir (second line use only) | tablets 125mg, 250mg, 750mg | |
5.3.2.2 Cytomegalovirus infection
Valganciclovir is used in the treatment of reactivated CMV in immunosuppressed patients treated with MabCampath® as per protocols at Manchester Royal Infirmary.
RED Ganciclovir injection 500mg vial (NHS England Commissioned) |
RED Valganciclovir tablets 450mg (NHS England Commissioned) |
RED Foscarnet Sodium (Foscavir®) (NHS England Commissioned) |
(cytomegalovirus retinitis in AIDS patients) |
RED Cidofovir capsules 250mg (Vistide®) (NHS England Commissioned) |
(cytomegalovirus retinitis in AIDS patients) |
RED Letermovir tablets 240mg (Prevymis ▼) | NICE TA591 recommended as an option for preventing cytomegalovirus reactivation and disease after an allogeneic | haematopoietic stem cell transplant in adults who are seropositive for CMV. NHS England Commissioned | |
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5.3.3 Viral Hepatitis
As per NICE guidance – see BNF. |
RED Adefovir dipivoxil tablets 10mg (Herpsera®) (NHS England Commissioned) |
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Entecavir - within its marketing authorisation, is recommended as an option for the treatment of people with chronic HBeAg-positive or HBeAg-negative hepatitis B in whom antiviral treatment is indicated. This guidance does not apply to people with chronic hepatitis B who also have hepatitis C, hepatitis D or HIV. |
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RED Entecavir (NHS England Commissioned) | |
tablets 500microgram, 1mg | oral solution 50microgram/ml | |
RED Tenofovir tablets 245mg |
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NICE TAG252 and NICE TAG253 approve the use of Telaprevir and Boceprevir for the treatment of Hepatitis C, genotype 1 |
RED Telaprevir (Invico®) tablets (NHS England Commissioned) | RED Boceprevir (Victrelis®) tablets (NHS England Commissioned) | |
NICE TAG300 recommends the use of Peginterferon alfa in combination with ribavirin as an option to treat chronic hepatitis C in children and young people |
RED Peginterferon alfa and ribavirin in combination (NHS England Commissioned) |
5.3.3.2 Chronic Hepatitis C
NHS England have issued a policy statement for treatment of chronic Hepatitis C in patients with cirrhosis which sets out treatments that will be routinely commissioned. The statement is available here.
The statement supports the use of Viekirax and Exviera and this is acknowledged. |
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Sofosbuvir -is recommended as an option for treating chronic hepatitis C in adults, as specified in NICE TA330 |
RED Sofosbuvir (Sovaldi®) tablets (NHS England Commissioned) |
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Sofosbuvir-velpatasvir - is recommended as an option for treating chronic hepatitis C in adults, as specified in attached table, only if the company provides the drug with the discount agreed in the simple discount agreement. NICE TA430 |
RED Sofosbuvir-velpatasvir (Epclusa) (NHS England Commissioned) |
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RED Sofosbuvir-velpatasvir-voxilaprevir is recommended as an option for treating chronic hepatitis C in adults, | only if it is used as specified in the attached table and the company provides the drug at the same price or | lower than that agreed with the Commercial Medicines Unit as per NICE TA507 | (NHS England Commissioned) | |
Simeprevir - in combination with peginterferon alfa nd ribavirin is recommended as a possible treatment for adults with genotype 1 or 4 chronic hepatitis C - NICE TA331 |
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RED Simeprevir (Olysio®) capsules (NHS England Commissioned) |
RED Ledispar-sofosbuvir (Harvoni®) (NHS England Commissioned) |
tablets 90mg, 400mg |
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Daclatasvir - is recommended as a possible treatment for adults with some types (called genotypes) of chronic hepatitis C , depending on their level of fibrosis. NICE TA364 |
RED Daclatasvir (Daklinza®) (NHS England Commissioned) | tablets 30mg, 60mg | |
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Ombitasvir- paritaprevir-ritonavir with or without dasabuvir is recommended, within its marketing authorisation, as an option for treating genotype 1 or 4 chronic hepatitis in adults - NICE TA365 |
RED Ombitasvir–paritaprevir–ritonavir (Viekirax®) (NHS England Commissioned) | tablets 12.5mg, 75mg, 50mg | |
RED Ribavirin tablets 200mg (NHS England Commissioned) |
5.3.4 Influenza
Oseltamavir and zanamivir are to be used in line with NICE guidance and local emergency planning agreements. Endorse prescription SLS.
GREEN Oseltamivir |
capsules 75mg |
suspension 60mg/5mL |
GREEN Zanamivir inhaler 5mg blisters x 4
5.3.5 Respiratory syncytial virus
Palivizumab is to be used in line with National Joint Committee of Vaccination and Immunisation guidance in the following circumstances:
1. Children under the age of 2 years with chronic lung disease who
- Have recieved oxygen for >28 days after birth;
- Are receiving home oxygen therapy
2. Infants less than 6 months of age who have left to right shunt haemodynamically significant congenital heart disease and /or pulmonary hypertension.
Supply of palivizumab should always be from pharmacy to individual patients; it should never be issued as stock. This allows recharging of the costs of palivizumab to the CCGs under ‘payment by results’ by allowing the tracing of all supplies.
RED Palivizumab injection 50mg, 100mg (NHS England Commissioned)