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1.2 ANTISPASMODICS AND OTHER DRUGS ALTERING GUT MOTILITY

1.2 Antispasmodics and other drugs altering gut motilit

      

       Useful as adjunctive treatment in non-ulcer dyspepsia, irritable bowel syndrome and diverticular disease, to reduce 
       intestinal  motility.
            GREEN     Mebeverine capsules 200mg (Colofac®MR)
            GREEN     Mebeverine tablets135mg (prescribe as Colofac®)  
            GREEN     Alverine Citrate capsules 60mg
            GREEN     Hyoscine butylbromide
                              tablets 10mg,    
                             injection 20mg/mL *WARNING see link below* 
                              *Drug Safety Update*  serious adverse effects in patients with underlying cardiac disease
            GREEN    Peppermint oil e/c capsules
            RED         Peppermint water
            AMBER   Dicycloverine 10mg/5mL oral solution. [Use restricted to paediatrics only, for continuation when initiated
                            by tertiary centres.]
 
            Metoclopramide and domperidone stimulate gastric emptying, small intestinal transit and enhance strength of oesophageal
            sphincter contraction. Avoid metoclopramide in children and those under 20 years of age because of the risk of dystonic 
            reactions.
            GREEN     Domperidone - see section 4.6
            GREEN     Metoclopramide- see section 4.6
 
            Eluxadoline is recommended as an option in treating irritable bowel syndrome with diarrhoea in adults as per 
            NICE guidance TA471
            RED         Eluxadoline tablets 75mg, 100mg (Truberzi®)  
 
 
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